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Related Antibodies

L 006235

L 006235

Catalog No. A4422
Size Price Stock Qty
10mg $214.00 Ship Within 5 Days
50mg $912.00 Ship Within 5 Days

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

L 006235

Biological Activity

Potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S.
Targets cathepsin K          
IC50 0.25nM          

L 006235 Dilution Calculator

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L 006235 Molarity Calculator

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Chemical Properties

Cas No. 294623-49-7 SDF Download SDF
Chemical Name N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide
Canonical SMILES CN1CCN(CC1)C2=NC(=CS2)C3=CC=C(C=C3)C(=O)NC4(CCCCC4)C(=O)NCC#N
Formula C24H30N6O2S M.Wt 466.6
Solubility Soluble in DMSO Storage Store at 4°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence.