KPT-9274
Catalog No.
B5937
Orally acitve allosteric inhibitor of PAK4
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KPT-9274 (CAS 1643913-93-2) is an orally bioavailable allosteric inhibitor selectively targeting p21-activated kinase 4 (PAK4), a serine/threonine kinase acting downstream of Rac1/Cdc42, implicated in cytoskeletal reorganization, β-catenin signaling, and tumor progression. KPT-9274 reduces proliferation, migration, and viability across multiple cancer models, including triple-negative breast cancer (MDA-MB-468 cells; IC50 = 0.12 μM), renal cell carcinoma, and acute myeloid leukemia (AML), by inhibiting PAK4 expression and downstream pathways. In vivo, orally administered KPT-9274 suppresses tumor growth and improves survival in xenograft mouse models, indicating its utility as a tool compound for cancer research.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 610.62 |
| Cas No. | 1643913-93-2 |
| Formula | C35H29F3N4O3 |
| Solubility | ≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | (1Z,2E)-3-(6-aminopyridin-2-yl)-N-((5-(4-(4,4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylimidic acid |
| SDF | Download SDF |
| Canonical SMILES | FC1=CC=C(C2=CC(C3=CC=C(C(N4CCC(F)(F)CC4)=O)C=C3)=CC5=C2OC(C/N=C(O)/C([H])=C([H])/C6=NC(N)=CC=C6)=C5)C=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
