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KNK437stress-induced HSP synthesis inhibitor

KNK437

Catalog No. B5848
Size Price Stock Qty
10mg $70.00 In stock
50mg $280.00 In stock
200mg $700.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

KNK437

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Chemical Properties

Cas No. 218924-25-5 SDF Download SDF
Chemical Name (E)-2-(benzo[d][1,3]dioxol-5-ylmethylene)-5-oxopyrrolidine-1-carbaldehyde
Canonical SMILES O=CN1/C(CCC1=O)=C([H])/C2=CC3=C(OCO3)C=C2
Formula C13H11NO4 M.Wt 245.23
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

KNK437 is a benzylidene lactam compound that inhibits stress-induced HSPs (heat shock proteins) synthesis.

HSPs (heat shock proteins) are chaperones that their expressions are increased under various cellular stresses including temperature rise. It plays a vital role in regulating protein folding and associated with cancer and cardiovascular diseases.

KNK437 inhibits the acquisition of thermotolerance and the induction of various HSPs in human colon carcinoma cells (COLO 320DM) in a dose-dependent manner. KNK437 also blocks the acquisition of thermotolerance that developed by sodium arsenite. [1]

KNK437 exerts low toxicity in vivo. In C3H/He mice transplanted with SCC VII cells, the concentration of KNK437 in the tumors gradually increases and reaches a peak 6 hours after i.p. injection. Hsp72 were synthesized 8 h after hyperthermia at 44 oC for 10 minutes, and their synthesis is inhibited by administration of KNK437 6 hours before hyperthermia. [2]

References:
1.  Yokota S, Kitahara M, Nagata K. Benzylidene lactam compound, KNK437, a novel
inhibitor of acquisition of thermotolerance and heat shock protein induction in
human colon carcinoma cells.  Cancer Res. 2000 Jun 1;60(11):2942-8.
2.  Koishi M, Yokota S, Mae T et al. The effects of KNK437, a novel inhibitor of heat shock protein
synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo.  Clin Cancer Res. 2001 Jan;7(1):215-9.