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Kif15-IN-2

Catalog No.
B3281
potent Kif15 kinesin inhibitor
Grouped product items
SizePriceStock Qty
2mg
$358.00
Ship with 10-15 days
5mg
$539.00
Ship with 10-15 days
10mg
$770.00
Ship with 10-15 days
50mg
$2,308.00
Ship with 10-15 days
100mg
$3,231.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Kif15-IN-2, a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].

Kif15,also known as Kinesin-12 and HKLP2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.KIF15 is involved in maintainingbipolar microtubulespindle apparatusin dividing cells and shares redundant functions withKIF11 [3].

References:
[1]. Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
[2].  Buster D W, Baird D H, Yu W, et al. Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development[J]. Journal of neurocytology, 2003, 32(1): 79-96.
[3].  Vanneste D, Takagi M, Imamoto N, et al. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity[J]. Current Biology, 2009, 19(20): 1712-1717.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt440.48
Cas No.672926-33-9
FormulaC20H20N6O4S
SolubilitySoluble in DMSO
Chemical Name(S,Z)-2-(2-hydroxy-4-oxoquinazolin-3(4H)-yl)-3-methyl-N-(4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)thiazol-2-yl)butanimidic acid
SDFDownload SDF
Canonical SMILESCC([[email protected]@](N1C(C2=CC=CC=C2N=C1O)=O)([H])/C(O)=N/C3=NC(C)=C(S3)C4=NN=C(O4)C)C
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Kif15-IN-2