Kif15-IN-2
Kif15-IN-2, a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].
Kif15,also known as Kinesin-12 and HKLP2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.KIF15 is involved in maintainingbipolar microtubulespindle apparatusin dividing cells and shares redundant functions withKIF11 [3].
References:
[1]. Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
[2]. Buster D W, Baird D H, Yu W, et al. Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development[J]. Journal of neurocytology, 2003, 32(1): 79-96.
[3]. Vanneste D, Takagi M, Imamoto N, et al. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity[J]. Current Biology, 2009, 19(20): 1712-1717.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 440.48 |
| Cas No. | 672926-33-9 |
| Formula | C20H20N6O4S |
| Solubility | Soluble in DMSO |
| Chemical Name | (S,Z)-2-(2-hydroxy-4-oxoquinazolin-3(4H)-yl)-3-methyl-N-(4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)thiazol-2-yl)butanimidic acid |
| SDF | Download SDF |
| Canonical SMILES | CC(C)[C@@H](C(Nc1nc(C)c(-c2nnc(C)[o]2)[s]1)=O)N1C(O)=Nc(cccc2)c2C1=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
