K-7174
Catalog No.
B5898
Orally active proteasome inhibitor
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K-7174 (CAS 191089-60-8) is an orally active small molecule acting as a proteasome inhibitor. By inhibiting the proteasome, K-7174 induces caspase-8-dependent degradation of Sp1, a transcription factor essential for the expression of class I histone deacetylases (HDACs). Consequently, K-7174 treatment leads to transcriptional repression of HDACs and promotes histone hyperacetylation. In vitro, the compound shows antiproliferative effects on multiple myeloma cells, including Bortezomib-resistant cells harboring β5 subunit mutations. In myeloma mouse models, oral K-7174 administration exhibits antitumor efficacy with minimal toxicity, highlighting its potential utility in anticancer research.
| Storage | Store at -20°C |
| M.Wt | 641.67 |
| Cas No. | 191089-60-8 |
| Formula | C33H50Cl2N2O6 |
| Solubility | ≥64.2 mg/mL in H2O; ≥51.6 mg/mL in EtOH; ≥61.8 mg/mL in DMSO |
| Chemical Name | 1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | COC1=C(OC)C(OC)=CC(/C([H])=C([H])/CCCN(CC2)CCCN2CCC/C([H])=C([H])/C3=CC(OC)=C(OC)C(OC)=C3)=C1.Cl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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