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Isoprenaline HCl

Catalog No.
B1336
β-adrenergic receptor agonist
Grouped product items
SizePriceStock Qty
1g
$50.00
In stock
5g
$150.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

Isoprenaline hydrochloride (CAS: 51-30-9) is a synthetic sympathomimetic amine functioning as a non-selective β-adrenoceptor agonist, structurally analogous to epinephrine. Its mechanism involves the stimulation of both β1- and β2-adrenergic receptors, resulting in increased cardiac output through enhanced chronotropic and inotropic effects, alongside bronchial smooth muscle relaxation. Due to these pharmacological properties, isoprenaline hydrochloride is utilized in research exploring cardiac arrhythmias, conduction disorders, bradycardia, and bronchospasm.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt247.72
Cas No.51-30-9
FormulaC11H17NO3·HCl
Solubility≥12.39 mg/mL in DMSO; ≥16.6 mg/mL in EtOH with gentle warming and ultrasonic; ≥50.2 mg/mL in H2O with gentle warming
Chemical Name4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;hydrochloride
SDFDownload SDF
Canonical SMILESCC(C)NCC(C1=CC(=C(C=C1)O)O)O.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]

Cell lines

Human umbilical vein endothelial cells (HUVECs)

Reaction Conditions

100 nmol/L isoprenaline for 20 h incubation

Applications

Isoprenaline resulted in significantly enhanced expression of endothelial Cx43 and to a lower degree of Cx40 and Cx37. The number of coupling cells was significantly increased. Regarding angiogenesis, isoprenaline led to significantly enhanced formation of branches and a higher complexity of the tube networks with more branches/length.

Animal experiment:[2]

Animal models

Male albino rats of the Sprague-Dawley strain, 225 ~ 325 g

Dosage form

0.33 mg/kg

Administered by subcutaneous injection

Applications

A subcutaneous injection of 0.33 mg/kg isoproterenol decreased blood pressure and increased water intake in nephrectomized rats.

Note

The technical data provided above is for reference only.

References:

1. Dhein S, Gaertner C, Georgieff C, et al. Effects of isoprenaline on endothelial connexins and angiogenesis in a human endothelial cell culture system. Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, 388(1): 101-108.

2. Hosutt JA, Rowland N, Stricker EM. Hypotension and thirst in rats after isoproterenol treatment. Physiology & Behavior, 1978, 21(4): 593-598.

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