In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis .
Antidepressants are antagonists of many neurotransmitter receptors in human brain .
Imipramine is the first tricyclic antidepressant that acts mainly as an inhibitor of serotonin and norepinephrine transporters . In radioligand binding assays, imipramine inhibited serotonin and norepinephrine transporters with KD values of 1.4 and 37 nM, respectively . Imipramine is also inhibited histamine H1 receptor, muscarinic acetylcholine receptor and α1-adrenergic receptor with Kd values of 37, 46, and 32 nM, respectively .
In rodents, imipramine abolished the depressive syndrome produced by the acute administration of reserpine. Imipramine also possessed central anticholinergic activity and attenuate the activity of the centrally acting muscarinic agents tremorine and oxotremorine. Imipramine inhibited the presynaptic uptake of NA and 5-HT, and relatively weak against DA .
. Spencer PS. Review of the pharmacology of existing antidepressants. Br J Clin Pharmacol. 1977;4Suppl 2:57S-68S.
. Tatsumi M, Groshan K, Blakely RD, et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58.
. Cusack B, Nelson A, Richelson E. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65.
|Storage||Store at -20°C|
|Solubility||≥12.5 mg/mL in DMSO; ≥22.3 mg/mL in H2O; ≥22.9 mg/mL in EtOH|
|Chemical Name||10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, monohydrochloride|
|Shipping Condition||Ship with blue ice, or upon other requests.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.|