In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Imipenem is one of the semisynthetic thienamycins with antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, which is stable to many beta-lactamases and shows a long half-life because of binding to plasma proteins .
Penicillin-binding proteins (PBPs) are a kind of membrane proteins, widely existing on the surface of bacteria, which is the main target site of beta-lactam antibiotics.
In E. coli and selected strains of P. aeruginosa, imipenem has shown to have the highest affinity to PBP-2, PBP-1a, and PBP-1b . The inhibition of PBPs reduces the number of peptidoglycan polymer in the bacterial cell, thus prevent the forming of the bacterial cell wall and lead to cell death .
. Zhanel G G, Wiebe R, Dilay L, et al. Comparative review of the carbapenems [J]. Drugs, 2007, 67(7): 1027-52.
. Nicolau D P. Carbapenems: a potent class of antibiotics [J]. Expert Opin Pharmacother. 2008, 9(1): 23-37.
. Brunton L L, Hilal-Dandan R, Knollmann B C. eds (2018). Goodman & Gilman's: The Pharmacological Basis of Therapeutics (13th ed.). McGraw-Hill Education.
|Physical Appearance||A solid|
|Storage||Store at -20°C|
|Solubility||≥29.9mg/mL in H2O with gentle warming|
|Chemical Name||(5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid|
|Canonical SMILES||C[[email protected]](O)([H])[[email protected]](C1=O)([H])[[email protected]@](N21)([H])CC(SCCNC=N)=C2C(O)=O|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|
Quality Control & MSDS
- View current batch:
Purity = 98.00%
- COA (Certificate Of Analysis)
- MS(Mass Spectrometry)
- NMR (Nuclear Magnetic Resonance)
- MSDS (Material Safety Data Sheet)