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IL-18, human recombinant protein

Catalog No.
P1032
IL-18, proinflammatory cytokine, expressed in E.Coli.
Grouped product items
SizePriceStock Qty
25ug
$257.00
Ship with 5-10 days
100ug
$693.00
Ship with 5-10 days
1mg
$4,752.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

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Background

Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures. Also, human IL-18 induces the production of IFN-γ and GM-CSF but inhibits the production of IL-10 by PBMC. IL-18 plays an important role in cell-mediated immune responses.

 The human IL-18 cDNA encodes a 193 aa protein with a 36 aa propeptide. Recombinant human IL-18 is an 18 kDa single, non-glycosylated polypeptide chain containing 157 amino acids.

Biological Activity

Determined by dose-dependent stimulation of the IFN-γ by human PBMC co-stimulated with rh-IL-12.
ED50 5 ng/ml.          

Quality Control

Quality Control & DataSheet

View current batch:
    Purity: ≥98%, by SDS-PAGE and HPLC.
    Endotoxin Level:<0.1 ng/μg

Related Biological Data

IL-18

Related Biological Data

IL-18

Related Biological Data

IL-18
 

Description

Gene ID: 3606 Accession #: Q14116
Alternate Names:Human IL-18, IL-18, IL18, IL 18, h-IL-18, rh-IL-18, recombinant human IL-18, recombinant IL-18, IL, interluekin.
Source: Escherichia Coli. M.Wt: 18.3 kDa
Appearance: Lyophilized protein Storage: Store at -20°C
Formulation:Sterile filtered and lyophilized from PBS.
Solubility:Reconstitute in ice-cold water to a concentration of 0.5-1 µg/µl.
Shipping Condition: Blue ice. Handling: Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.