Toggle Nav

GW0742

In stock
Catalog No.
A4307
PPARδ/β agonist,potent and selective
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$65.00
In stock
5mg
$60.00
In stock
10mg
$102.00
In stock
50mg
$329.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

GW0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI.

Reference

Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Salvatore Cuzzocrea. GW0742, a selective PPAR-β/δ agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury. August 2010. Journal of Leukocyte Biology. vol. 88 no. 2 291-301

Caroline I. Schnegg, Dana Greene-Schloesser, Mitra Kooshki, Valerie S. Payne, Fang-Chi Hsud, Mike E. Robbins. hippocampal-dependent cognitive impairment after whole-brain irradiation. Free Radical Biology and Medicine. Volume 61, August 2013, Pages 1–9.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt471.49
Cas No.317318-84-6
FormulaC21H17F4NO3S2
SynonymsGW 0742
Solubility≥47.1 mg/mL in DMSO, ≥49.7 mg/mL in EtOH with ultrasonic and warming, <2.59 mg/mL in H2O
Chemical Name2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid
SDFDownload SDF
Canonical SMILESCC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC(=C(C=C3)C(F)(F)F)F)C)OCC(=O)O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description GW0742 is a selective agonist of PPARδ with EC50 value of 1.1 nM.
Targets PPARδ          
IC50 1.1 nM (EC50)          

Quality Control

Chemical structure

GW0742