Gentamycin Sulfate
Catalog No.
A2514
Aminoglycoside antibiotic
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Gentamycin sulfate (CAS 1405-41-0) is an aminoglycoside antibiotic commonly utilized in biomedical research for its bactericidal activity against a broad spectrum of bacterial pathogens, particularly Gram-negative aerobes. Its mechanism involves irreversible binding to the bacterial 30S ribosomal subunit, specifically interacting with 16S rRNA nucleotides near nucleotide 1400 and ribosomal protein S12. This binding disrupts accurate decoding of mRNA, resulting in incorporation of incorrect amino acids into nascent peptides and the formation of defective or toxic proteins. Gentamycin sulfate serves as a valuable tool in research exploring bacterial protein synthesis, ribosome function, antibiotic resistance, and microbial pathogenicity.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1506.80 |
| Cas No. | 1405-41-0 |
| Formula | C60H127N15O26S |
| Solubility | ≥51.1 mg/mL in H2O; insoluble in DMSO; insoluble in EtOH |
| Chemical Name | sulfuric acid compound with (2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-diamino-3-(((2R,3R,6R)-3-amino-6-((R)-1-(methylamino)ethyl)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-5-methyl-4-(methylamino)tetrahydro-2H-pyran-3,5-diol and (2R,3R,4R,5R)-2-( |
| SDF | Download SDF |
| Canonical SMILES | C[C@]1(O)CO[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@@]([H])([C@@H](C)NC)CC[C@H]3N)[C@@H]2O)[C@H](O)[C@H]1NC.C[C@]4(O)CO[C@H](O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6O[C@H](CN)CC[C@H]6N)[C@@H]5O)[C@H](O)[C@H]4NC.C[C@]7(O)CO[C@H](O[C@H]8[C@H](N)C[C@H]( |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
