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Flavin adenine dinucleotide

Flavin adenine dinucleotide

Catalog No.

B7885

A redox cofactor (electron carrier), involved in several important enzymatic reactions in metabolism

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Size	Price	Stock	Qty
10mg	$50.00	In stock
50mg	$100.00	In stock

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Background
Chemical Properties
Protocol
Quality Control

Background

Flavin adenine dinucleotide is used as a redox cofactor by a variety of proteins involved in several important enzymatic reactions in metabolism. In human, most flavoproteins contain one or more loosely bound flavin adenine dinucleotide moieties. Flavoproteins include the succinate dehydrogenase complex, α-ketoglutarate dehydrogenase, folate/FAD-dependent tRNA methyltransferases, N-hydroxylating flavoprotein monooxygenases, and apoptosis-inducing factor 2. Flavoproteins are predominately located in the mitochondria due to their redox power. Of all flavoproteins, more than 90% perform redox reactions and ~ 10% are lyases, transferases, isomerases and ligases involved in nonredox reactions.

References:

1. Kohlmeier M. Chapter 10 - Water-Soluble Vitamins and Nonnutrients. Nutrient Metabolism (Second Edition), 2015, 567-671.

2. Lienhart WD, Gudipati V, Macheroux P. The human flavoproteome. Archives of Biochemistry and Biophysics, 2013, 535(2): 150-162.

3. Macheroux P, Kappes B, Ealick SE. Flavogenomics--a genomic and structural view of flavin-dependent proteins. The FEBS Journal, 2011, 278(15): 2625-2634.

4. Sugiyama S, Ozawa T. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Japanese Heart Journal, 1979, 20(5): 657-665.

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	785.55
Cas No.	146-14-5
Formula	C₂₇H₃₃P₂N₉O₁₅
Solubility	insoluble in EtOH; insoluble in DMSO; ≥196.5 mg/mL in H2O
SDF	Download SDF
Canonical SMILES	CC1=CC(N=C(C(O)=N2)C3=NC2=O)=C(N3C[C@@](O)([H])[C@@](O)([H])[C@@](O)([H])COP(O)(OP(O)(OC[C@](O4)([H])[C@](O)([H])[C@](O)([H])[C@]4([H])N5C=NC(C5=NC=N6)=C6N)=O)=O)C=C1C
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment:[4]
Animal models	Dogs
Dosage form	2 mg/kg Intravenous injection
Applications	Flavin adenine dinucleotide significantly canceled the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Also, flavin adenine dinucleotide counteracted the effects of CPZ on canine heart mitochondria. Thus, flavin adenine dinucleotide might be useful in the treatment of the cardiac disturbances associated with overdosage of CPZ.
Note	The technical data provided above is for reference only.
	References: 1. Kohlmeier M. Chapter 10 - Water-Soluble Vitamins and Nonnutrients. Nutrient Metabolism (Second Edition), 2015, 567-671. 2. Lienhart WD, Gudipati V, Macheroux P. The human flavoproteome. Archives of Biochemistry and Biophysics, 2013, 535(2): 150-162. 3. Macheroux P, Kappes B, Ealick SE. Flavogenomics--a genomic and structural view of flavin-dependent proteins. The FEBS Journal, 2011, 278(15): 2625-2634. 4. Sugiyama S, Ozawa T. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Japanese Heart Journal, 1979, 20(5): 657-665.

Quality Control

Quality Control & MSDS

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Purity = 99.36%

Chemical structure

Flavin adenine dinucleotide

mRNA synthesis

Tyramide Signal Amplification (TSA)

Phos Binding Reagent Acrylamide

Cell Counting Kit-8 (CCK-8)

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