Toggle Nav
Close
  • Menu
  • Setting

Ethacrynic Acid

Catalog No.
C4125
A loop diuretic that inhibits the Na+/K+/2Cl- cotransporter (NKCC2)
Grouped product items
SizePriceStock Qty
1g
$65.00
Ship with 10-15 days
5g
$310.00
Ship with 10-15 days
10g
$586.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Ethacrynic acid is one of the most used loop diuretics, acting by inhibiting NKCC2 which is specifically found in the thick ascending loop of Henle in the kidneys. Inhibition of NKCC2 significantly increases the concentrations of Na+, K+, and Cl in the tubule, and reduces hypertonicity in the surrounding interstitium, causing less water to be reabsorbed into the blood. Eventually, more urine will be produced and excreted, and a decrease in blood volume can be achieved. Loop diuretics have been used for the treatment of fluid overload/edema in congestive heart failure, acute pulmonary edema, nephrotic syndrome, hepatic ascites, renal failure, as well as other edematous disorders. 

References:

1. Vardanyan R, Hruby V. Synthesis of Best-Seller Drugs. Chapter 21 - Diuretics, 2016, 317-327.

2. Zins GR, Walk RA, Gussin RZ, et al. The diuretic activity of ethacrynic acid in rats. Journal of Pharmacology and Experimental Therapeutics, 1968, 163(1): 210-215.

Chemical Properties

StorageStore at -20°C
M.Wt303.14
Cas No.58-54-8
FormulaC13H12Cl2O4
SynonymsMK 595,NSC 85791,NSC 624008
Solubilityinsoluble in H2O; ≥15.15 mg/mL in DMSO; ≥44.4 mg/mL in EtOH
Chemical Name2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetic acid
SDFDownload SDF
Canonical SMILESO=C(O)COC1=CC=C(C(C(CC)=C)=O)C(Cl)=C1Cl
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment:[2]

Animal models

Rats

Dosage form

37.5 and 125 mg/kg

Intravenous administration

Applications

Single doses of 37.5 and 125 mg/kg increased water and potassium excretion 2-fold, sodium excretion 3-fold and chloride excretion 4-fold in relation to parallel control animals. Single dose activity was confined to the 1st hr after injection whereas effects persisted for the duration of observation when animals were primed with 25 mg/kg and sustained with 50 mg/kg/hr.

Note

The technical data provided above is for reference only.

References:

1. Vardanyan R, Hruby V. Synthesis of Best-Seller Drugs. Chapter 21 - Diuretics, 2016, 317-327.

2. Zins GR, Walk RA, Gussin RZ, et al. The diuretic activity of ethacrynic acid in rats. Journal of Pharmacology and Experimental Therapeutics, 1968, 163(1): 210-215.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Ethacrynic Acid