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Epidermal growth factor receptor (994-1002) acetyl/amide
EGF-family receptor

Epidermal growth factor receptor (994-1002) acetyl/amide

Catalog No. A1133
Size Price Stock Qty
1mg $40.00 In stock
5mg $120.00 In stock
10mg $200.00 In stock
25mg $280.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Epidermal growth factor receptor (994-1002) acetyl/amide

Epidermal growth factor receptor (994-1002) acetyl/amide Dilution Calculator

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Chemical Properties

Cas No. SDF Download SDF
Synonyms Ac-Asp-Ser-Asn-Phe-Tyr-Arg-Ala-Leu-Met-amide
Canonical SMILES OC(CC(NC(C)=O)C(NC(CO)C(NC(CC(N)=O)C(NC(CC1=CC=CC=C1)C(NC(CC2=CC=C(O)C=C2)C(NC(CCCNC(N)=N)C(NC(C)C(NC(CC(C)C)C(NC(CCSC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Formula C51H76N14O15S M.Wt 1157.3
Solubility Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 inhumans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands(1). EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α (TGFα). Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer, anal cancers and glioblastoma multiforme(2). In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed. Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers. Mutations involving EGFR could lead to its constant activation, which could result in uncontrolled cell division – a predisposition for cancer. Consequently, mutations of EGFR have been identified in several types of cancer, and it is the target of an expanding class of anticancer therapies(3).

A1133_1

Figurethe structures of Epidermal growth factor receptor

A1133_2

Figure2  EGF signaling pathways

Ref:

1. Herbst RS (2004). "Review of epidermal growth factor receptor biology". Int. J. Radiat. Oncol. Biol. Phys. 59 (2 Suppl): 21–6.

2. Walker F, Abramowitz L, Benabderrahmane D, Duval X, Descatoire V, Hénin D, Lehy T, Aparicio T (November 2009). "Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus". Hum. Pathol. 40 (11): 1517–27.

3. Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI (August 2007). "ErbB receptors: from oncogenes to targeted cancer therapies". J. Clin. Invest. 117 (8): 2051–8.