In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Eicosapentaenoic acid is a type of n-3 polyunsaturated fatty acids (n-3 PUFA) .
n-3 PUFA are widely used in cardiovascular medicine and lipid-lowering intervention. n-3 PUFA can change the fatty acid composition of the membranes and affect different types of membrane proteins .
In endothelial cell line H5V, eicosapentaenoic acid at 100 μM inhibited cell migration into a wound, triggered peripheral distribution of focal adhesions and caused partial disassembly of actin filaments . In addition, at 1 ~ 5 μM, eicosapentaenoic acid inhibited oxidation of very large density lipoprotein in a dose-dependent manner over time .
In human subjects with diets high in eicosapentaenoic acid, either as a cod liver oil (40 ml = 4 g eicosapentaenoic acid daily) supplement to their normal Western diet for 24 days, or with mackerel (750 g = 10 ~ 15 g eicosapentaenoic acid daily) as the sole source of protein and lipids, for 3 days, eicosapentaenoic acid increased prostaglandin I3 formation in vivo, providing protection against heart diseases .
. Tonutti L, Manzi L, Tacconi M T, et al. Eicosapentaenoic acid inhibits endothelial cell migration in vitro. Journal of angiogenesis research, 2010, 2(12): 1-8.
. Preston Mason R, Sherratt S C R. Eicosapentaenoic acid inhibits oxidation of very large density lipoprotein in a dose-dependent manner over time as compared to docosaheaenoic acid in vitro. Journal of the American College of Cardiology, 2020, 75(11): 2238.
. Evidence of prostaglandin I3 formation in vivo from dietary eicosapentaenoic acid. Nutrition Reviews, 1984, 42(9): 317-318.
|Physical Appearance||A yellow oil|
|Storage||Store at -20°C|
|Solubility||≥116.8 mg/mL in DMSO; ≥49.3 mg/mL in H2O; ≥52.5 mg/mL in EtOH|
|Chemical Name||(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|
Quality Control & MSDS
- View current batch:
Purity = 99.12%
- COA (Certificate Of Analysis)
- NMR (Nuclear Magnetic Resonance)
- MSDS (Material Safety Data Sheet)