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DMPO

Catalog No.
B7401
Water soluble nitric oxide spin trap
Grouped product items
SizePriceStock Qty
50mg
$98.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

DMPO is a kind of water soluble nitric oxide spin trap, which allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance (ESR). [1] 

It has a high reaction rate constant for superoxide and hydroxyl radicals, and distinguishes simultaneously among a variety of important biologically generated free radicals. [1][2] 

In vitro,  It was demonstrated in red blood cells and in hamster V79 cells that the DMPO spin adducts of ·O2 and ·OH are metabolized very rapidly so that even if formed, they may not be detected in many experiments with cells.[1] 

In vivo, when DMPO perfused the heart at 100 μm/L, it attenuated the development of reperfusion arrhythmias during the first 10 min of reperfusion and improved the functional recovery of the heart during reperfusion. Without treatment, 55% of hearts showed irreversible ventricular fibrillation, and this was completely prevented by DMPO, due to its function of traping·O2 and ·OH radicals.[2] 

References:

[1] Samuni A1, Samuni A, Swartz HM. The cellular-induced decay of DMPO spin adducts of ·O2 and ·OH. Free Radic Biol Med. 1989; 6(2):179-83.

[2] Tosaki A1, Blasig IE, Pali T, et al. Heart protection and radical trapping by DMPO during reperfusion in isolated working rat hearts. Free Radic Biol Med. 1990; 8 (4):363-72.

Product Citation

Chemical Properties

Physical AppearanceA colorless oil
StorageStore at -20°C
M.Wt113.16
Cas No.3317-61-1
FormulaC6H11NO
Solubility≥11.3 mg/mL in DMSO; ≥55.9 mg/mL in H2O; ≥65.8 mg/mL in EtOH
Chemical Name2,2-dimethyl-3,4-dihydro-2H-pyrrole 1-oxide
SDFDownload SDF
Canonical SMILES[O-][N+]1=CCCC1(C)C
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

DMPO

Related Biological Data

DMPO