Diphenyleneiodonium chloride
Catalog No.
B6326
iNOS and eNOS inhibitor,GPR3 Activator
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Diphenyleneiodonium chloride (DPI, CAS 4673-26-1) is an agonist of G protein-coupled receptor 3 (GPR3), a Gs-linked GPCR that promotes intracellular cAMP accumulation. In GPR3-expressing HEK293 cells, DPI elevates cAMP levels independently from its known inhibitory actions on NADH oxidases (NOX). DPI also induces receptor desensitization, calcium influx, and β-arrestin2 recruitment in HeLa cells transfected with GPR3. Additionally, DPI potently inhibits NOX activity (EC50=0.1 μM), nitric oxide synthase irreversibly, and cytochrome P450 reductase (Ki=2.8 μM). DPI is broadly utilized for probing cAMP-related signaling and redox enzyme functions.
- 1. Yu Cao, Minghui Chen, et al. "Neutrophil extracellular traps mediate the crosstalk between plaque microenvironment and unstable carotid plaque formation." Exp Mol Med. 2024 Aug 1 PMID: 39085350
- 2. Mingze Ma, Fengxian Shi, et al. "TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells." Mol Biol Rep. 2021 Mar;48(3):2365-2375. PMID:33792826
- 3. Yang PM, Hong YH, et al. "Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units." Oxid Med Cell Longev. 2020 Apr 4;2020:7289120. PMID:32322337
| Physical Appearance | A crystalline solid |
| Storage | Desiccate at -20°C |
| M.Wt | 314.55 |
| Cas No. | 4673-26-1 |
| Formula | C12H8ClI |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥6.99 mg/mL in DMSO with ultrasonic |
| Chemical Name | dibenzo[b,d]iodol-5-ium chloride |
| SDF | Download SDF |
| Canonical SMILES | C12=CC=CC=C1[I+]C3=CC=CC=C23.[Cl-] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
