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Catalog No.
Androgen receptor agonist
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Dihydrotestosterone is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor . 

In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increases the expression of EGFR and ERBB2 both in mRNA and in protein levels. In AR-positive cell,DHT additionally upregulates the levels of phosphorylation of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment[1]. 

DHT-treated SOD1-G93A mice demonstrate ameliorated muscle atrophy and increased body weight, which is associated with stronger grip-strength. DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert myotrophic as well as neurotrophic effects through retrograde transport. DHT treatment attenuates neuromuscular junction denervation, and axonal and motoneuron loss. DHT-treated SOD1-G93A mice demonstrates improvement in motor behavior as assessed by rota-rod and gait analyses, and an increased lifespan[2]. 


[1]. Zheng Y, Izumi K, Yao J L, et al. Dihydrotestosterone upregulates the expression of epidermal growth factor receptor and ERBB2 in androgen receptor-positive bladder cancer cells. Endocrine Related Cancer, 2011, 18(4): 451-464.

[2]. Young-Eun Y, Chien-Ping K, Lin M. Dihydrotestosterone Ameliorates Degeneration in Muscle, Axons and Motoneurons and Improves Motor Function in Amyotrophic Lateral Sclerosis Model Mice. PLoS ONE, 2012, 7(5): e37258-.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.521-18-6
Solubility≥29mg/mL in DMSO
Chemical Name(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyltetradecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
SDFDownload SDF
Canonical SMILESC[[email protected]]12CCC(C[[email protected]]1([H])CC[[email protected]@]3([H])[[email protected]]4([H])CC[[email protected]](O)[[email protected]@](CC[[email protected]@]32[H])4C)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure