In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Deoxynivalenol, also known as vomitoxin, is a foodborne mycotoxin, acting as a potent inhibitor of protein synthesis. It stimulates the pro-inflammatory response, causes ribotoxic stress, cytotoxicity and apoptosis, as well as results in the impairment of multiple physiological functions, such as the intestinal barrier, growth, immune regulation and reproduction .
In immortalized human kidney epithelial cells, deoxynivalenol induced cytotoxicity, with EC50 value of 1.1 µM . In cloned macrophages and monocytes, the Jurkat human T-cell model, and cloned B cells, deoxynivalenol triggered apoptosis at concentrations ranging from 100 to 1000 ng/ml .
In swine, 50 µg/kg deoxynivalenol (i.p. or oral) could elicit emesis. Rapid onset of vomiting in pigs also occurred upon ingestion of feed contaminated with 19.7 ppm deoxynivalenol. Swine consuming 2 and 4 ppm deoxynivalenol exhibited a dose-related decrease in weight gain within the first 8 weeks of feeding, with 4 ppm causing decreased feed intake, weight gain, and efficiency of feed utilization throughout the experiment .
. Vidal A, Claeys L, Mengelers M, et al. Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours. Scientific Reports, 2018, 8(1): 5255.
. Bretz M, Beyer M, Cramer B, et al. Thermal degradation of the Fusarium mycotoxin deoxynivalenol. Journal of Agricultural and Food Chemistry, 2006, 54(17): 6445-6451.
. Pestka J J. Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance. Archives of Toxicology, 2010, 84(9): 663-679.
|Physical Appearance||A crystalline solid|
|Storage||Store at -20°C|
|Solubility||Soluble in DMSO|
|Canonical SMILES||O[[email protected]]1[[email protected]]2O[[email protected]](C=C(C)C3=O)[[email protected]@]([[email protected]@H]3O)(CO)[[email protected]](C1)(C)[[email protected]@]24OC4|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|