Decanoyl-RVKR-CMK
Catalog No.
B5437
Subtilisin/Kex2p-like proprotein convertase inhibitor
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Decanoyl-RVKR-CMK (CAS 150113-99-8) is a small molecule inhibitor targeting proprotein convertases (PCs), enzymes responsible for processing precursor proteins into biologically active peptides and activating various enzymes and growth factors. This inhibitor has been observed to suppress regulated secretion and maturation of the neuroendocrine peptide VGF in PC12 cells. Additionally, topical administration inhibited epidermal proliferation induced by phorbol ester treatment in K5-PACE4 transgenic mice and reduced basal keratinocyte proliferation. Decanoyl-RVKR-CMK is relevant in studies investigating PCs as potential targets for therapeutic approaches in cancer and related proliferative disorders.
- 1. Fei Yu, Jiehua Xu, et al. "Proprotein convertase cleavage of Ictalurid herpesvirus 1 spike-like protein ORF46 is modulated by N-glycosylation." Virology. 2024 Apr:592:110008. PMID: 38335866
- 2. Xiaoman Liu, Liang Wei, et al. "SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response." Sci Signal. 2022 Apr 12;15(729):eabg8744. PMID: 35412852
- 3. David Zaragoza-Huesca, Carlos Martínez-Cortés, et al. "Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors." Int J Mol Sci. 2022 Mar 3;23(5):2796. PMID: 35269938
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 744.42 |
| Cas No. | 150113-99-8 |
| Formula | C34H66ClN11O5 |
| Solubility | Soluble in H2O |
| Chemical Name | (2S,5R,8R,11S)-5-(4-aminobutyl)-2,11-bis(3-((diaminomethylene)amino)propyl)-8-isopropyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazatricosan-1-oyl chloride |
| SDF | Download SDF |
| Canonical SMILES | ClC([C@H](CCC/N=C(N)\N)NC([C@@H](CCCCN)NC([C@@H](C(C)C)NC([C@H](CCC/N=C(N)\N)NC(CCCCCCCCCC)=O)=O)=O)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity ≥95.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
Related Biological Data
Related Biological Data
