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DCPIB

Catalog No.
B6780
volume-sensitive anion channel (VSAC) and and ICl,swell blocker
Grouped product items
SizePriceStock Qty
10mg
$160.00
In stock
50mg
$630.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

DCPIB is a volume-regulated anion channel (VRAC) blocker (IC50 = 2 μM in rat pancreatic β-cells)[1], which is also a blocker of swelling-induced chloride current (ICl, swell) in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells)[2]. 

In intact β-cells, DCPIB inhibits glucose-stimulated insulin secretion through VSAC inhibition and indirect KATP channel activation. DCPIB reverses the shortened duration of action potential induced by cell swelling in atrial myocytes and inhibits astrocyte swelling in vitro. DCPIB (10 μM) also activates TREK1 and TRAAK K+ channels and inhibits TRESK, TASK1 and TASK3 K+ channels in vitro[3]. 

References:

[1]. Best L, Yates A P, Decher N, et al. Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. european journal of pharmacology, 2004, 489(1-2): 13-19.

[2].Decher N, et al. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol, 2001, 134(7): 1467-79.

[3]. Lv J, et al. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci, 2019.

Product Citation

Chemical Properties

Physical AppearanceWhite solid
StorageStore at -20°C
M.Wt427.37
Cas No.82749-70-0
FormulaC22H28Cl2O4
Solubilityinsoluble in H2O; ≥49.8 mg/mL in EtOH; ≥50.8 mg/mL in DMSO
Chemical Name(R)-4-((2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid
SDFDownload SDF
Canonical SMILESClC1=C2C([[email protected]@](CC2=CC(OCCCC(O)=O)=C1Cl)(CCCC)C3CCCC3)=O
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

DCPIB

Related Biological Data

DCPIB