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DCA

Catalog No.
B7174
mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor
Grouped product items
SizePriceStock Qty
10g
$45.00
In stock
50g
$150.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

Sodium dichloroacetate (DCA) is a specific inhibitor of pyruvate dehydrogenase kinase (PDK), with IC50 values of 183 μM and 80 μM for PDK2 and PDK4, respectively. DCA can inhibit the mitochondrial potassium channel axis, cause cancer cell apoptosis and inhibit tumor growth[1]. 

After DCA treatment, ROS levels in cancer cells increased, MMP depolarization, which can increase apoptosis both in vivo and in vitro[2]. 

In C57BL/6 mice, in vivo administration of DCA induced a 20% increase in survival and reduced tumor diameter, volume, and weight without affecting its weight and avoiding metastasis[3]. 

References:

[1]. Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. Journal of Biological Chemistry, 2014, 289(7): 4432-4443.

[2]. Sun R C, Board P G, Blackburn A C. Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells. Molecular Cancer, 2011, 10(1): 142.

[3]. Franco-Molina M A, Mendoza-Gamboa E, Sierra-Rivera C A, et al. In vitro and in vivo antitumoral activitiy of sodium dichloroacetate (DCA-Na) against murine melanoma. African journal of microbiology research, 2012, 6(22): 4782-4796.

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at RT
M.Wt150.92
Cas No.2156-56-1
FormulaC2HCl2NaO2
Solubility≥15.1 mg/mL in DMSO with gentle warming; ≥46.3 mg/mL in EtOH; ≥62.7 mg/mL in H2O
Chemical Namesodium 2,2-dichloroacetate
SDFDownload SDF
Canonical SMILESClC(C([O-])=O)Cl.[Na+]
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

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