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CU CPT 4a

Catalog No.
B5752
TLR3 inhibitor
Grouped product items
SizePriceStock Qty
10mg
$323.00
Ship with 5-10 days
50mg
$1,343.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

CU CPT 4a is a selective TLR3 inhibitor with IC50 of 3.44 μM in RAW 264.7 cells. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells. It reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome. 

References:

[1]. Cheng K, Wang X, Yin H. Small-Molecule Inhibitors of the TLR3/dsRNA Complex. Journal of the American Chemical Society, 2011, 133(11): 3764-3767.

[2]. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nature Communications, 2014, 5.

Chemical Properties

Physical AppearanceWhite solid
StorageStore at -20°C
M.Wt377.82
Cas No.1279713-77-7
FormulaC18H13ClFNO3S
Solubility<37.78mg/ml in DMSO
Chemical Name(R,Z)-2-(((3-chloro-6-fluorobenzo[b]thiophen-2-yl)(hydroxy)methylene)amino)-3-phenylpropanoic acid
SDFDownload SDF
Canonical SMILESClC(C1=C(S2)C=C(F)C=C1)=C2/C(O)=N/[[email protected]](C(O)=O)([H])CC3=CC=CC=C3
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

CU CPT 4a