CNQX disodium salt
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CNQX disodium salt is an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate receptors, with IC50 values of 0.3 and 1.5 μM, respectively .
AMPA and kainate receptors, collectively referred to as non-N-methyl-D-aspartate receptors, are distinct receptor complexes, but activated by the same agonists. AMPA and kainate receptors are involved in rapidly desensitizing responses in central nervous system .
In thalamic reticular nucleus neurons, CNQX (20 μM) depolarized all cells tested in a similar manner as DNQX. With longer CNQX application (5 min vs. 1 min), the depolarization persisted throughout CNQX application. However, in ventrobasal neurons, CNQX (20 μM) produced negligible effects on the membrane potential .
In Sprague-Dawley rats, pretreatment with CNQX (0.02, 0.1, 0.6, 3 and 15 mg/kg), administered intraperitoneally 15 min before capsaicin, significantly reduced c-fos-labelled cells within trigeminal nucleus caudalis by a maximum of 45%. The number of c-fos-like immunoreactivity cells within lateral reticular, medullary reticular, and solitary tract nuclei was not affected .
. Honoré T, Davies S N, Drejer J, et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science, 1988, 241(4866): 701-703.
. Bettler B, Mulle C. AMPA and kainate receptors. Neuropharmacology, 1995, 34(2): 123-139.
. Lee S H, Govindaiah G, Cox C L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. Journal of Neurophysiology, 2010, 103(4): 1728-1734.
. Mitsikostas D D, Sanchez del Rio M, Waeber C, et al. Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis. British Journal of Pharmacology, 1999, 127(3): 623-630.
|Physical Appearance||A solid|
|Storage||Desiccate at RT|
|Solubility||≥27.6mg/mL in DMSO|
|Chemical Name||sodium 6-cyano-7-nitroquinoxaline-2,3-bis(olate)|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|
Quality Control & MSDS
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