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CJ-42794

Catalog No.
C4037
EP4 antagonist
Grouped product items
SizePriceStock Qty
50mg
$273.00
In stock
100mg
$431.00
In stock
250mg
$861.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

CJ-42794 (CAS 847728-01-2) is a potent and selective antagonist targeting prostaglandin E receptor subtype 4 (EP4). It exhibits high affinity for EP4 receptors (Ki: 3.16 nM) with significantly lower potency at EP2 receptors (Ki: 631 nM), and negligible affinity for EP1 or EP3. By blocking EP4-mediated signaling, CJ-42794 prevents prostaglandin E2-induced intracellular cAMP elevation, thereby reversing PGE2-dependent inhibition of inflammatory responses, such as lipopolysaccharide-induced TNF-α secretion. In animal models, administration of CJ-42794 delays gastric ulcer healing through suppression of VEGF expression and angiogenesis. This compound serves as a valuable tool for investigating EP4-associated physiological and pathological processes.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt413.8
Cas No.847728-01-2
FormulaC22H17ClFNO4
SynonymsRQ-00015986
Solubilityinsoluble in H2O; ≥11.7 mg/mL in DMSO; ≥54.6 mg/mL in EtOH
Chemical Name4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-benzoic acid
SDFDownload SDF
Canonical SMILESFC1=CC=C(OC2=C(C(N[C@@H](C)C3=CC=C(C(O)=O)C=C3)=O)C=C(Cl)C=C2)C=C1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control