In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities .
Ciprofloxacin functions by inhibiting DNA gyrase and topoisomerase IV, the enzymes responsible for negative supercoiling of chromosomes and DNA strand separation, thus blocking initiation of bacterial replication. Topoisomerase IV is the primary target of ciprofloxacin in S. aureus .
Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that acts as an antimicrobial and immunomodulatory agent. In B6D2F1/J mice received radiation combined injury (CI), Ciprofloxacin significantly reduced pro-inflammatory cytokine and chemokine concentrations (IL-6 and KC), and enhanced IL-3 production. CIP also inhibited CI-induced apoptosis and autophagy in ileal villi, systemic bacterial infection, and IgA production . Ciprofloxacin (hydrochloride) had been approved by FDA for management of postexposure inhalational anthrax. In animals after exposure to aerosolized B. anthracis, ciprofloxacin significantly improved survival rate. Ciprofloxacin inhibited the growth of B. anthracis with MIC90 of 0.06 μg/mL. In the USAMRIID rhesus monkey model of inhalational anthrax, the maximum concentration (Cmax) of Ciprofloxacin was 1.74 μg/mL and the minimum concentration (Cmin) was 0.17 μg/mL .
. Fukumoto R, Cary LH, Gorbunov NV, et al. Ciprofloxacin modulates cytokine/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma. PLoS One. 2013;8(3):e58389.
. Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92.
. Meyerhoff A, Albrecht R, Meyer JM, et al. US Food and Drug Administration approval of ciprofloxacin hydrochloride for management of postexposure inhalational anthrax. Clin Infect Dis. 2004 Aug 1;39(3):303-8.
|Physical Appearance||A crystalline solid|
|Storage||Store at -20°C|
|Synonyms||BAY-o 9867,NSC 620634|
|Solubility||Soluble in DMSO|
|Chemical Name||1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, monohydrochloride|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|