In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50: 90 microM for the antiperoxidant potency
Cepharanthine is a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, which is widely used for the treatment of many acute and chronic diseases. The extract of Stephania cepharantha Hayata contains biscoclaurine alkaloids such as cepharanthine, which have been used widely for the treatment of radiation-induced leukopenia.
In vitro: Cepharanthine was found to exert antitumor effects by augmenting the immunological responses of the host, or by exerting apoptosis-inducing effects .
In vivo: Combined therapy of cepharanthine and S-1 (a new oral antineoplastic agent) showed antitumor effects on human OSCC xenografts and induced apoptotic cells in tumors significantly. Immunohistochemistry results showed TS and DPD expressions down-regulated and OPRT expression up-regulated in tumors treated with cepharanthine plus S-1 .
Clinical trial: In order to examine the clinical efficacy of cepharanthin for preventing chemotherapy-caused leukopenia in lung cancer patients, a randomized trial was carried out. The results suggested that administration of cepharanthin had an obvious antileukopenic effect in anticancer treatment, which made it possible to reduce the period of risk for infection and allow effective regimens to be repeatedly administered in a shorter interval .
 Furusawa S,Wu J. The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: implications for cancer, shock, and inflammatory diseases. Life Sci.2007 Feb 27;80(12):1073-9.
 Harada K,Ferdous T,Itashiki Y,Takii M,Mano T,Mori Y,Ueyama Y. Effects of cepharanthine alone and in combination with fluoropyrimidine anticancer agent, S-1, on tumor growth of human oral squamous cell carcinoma xenografts in nude mice. Anticancer Res.2009 Apr;29(4):1263-70.
 Saito R,Tsuchiya S,Ishizuka T,Fueki N,Ezawa K,Minato K,Nakano H,Takise A,Kurihara M,Fueki R. Clinical effects of cepharanthin (Ceph.) on leukopenia by chemotherapy in lung cancer patients. Nihon Gan Chiryo Gakkai Shi.1989 Dec 20;24(11):2587-93.
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|Physical Appearance||A solid|
|Storage||Store at -20°C|
|Solubility||≥21.9 mg/mL in DMSO; insoluble in H2O; ≥24.6 mg/mL in EtOH|
|Shipping Condition||Ship with blue ice, or upon other requests.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.|