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Cathepsin S inhibitor

Cathepsin S inhibitor

Catalog No. A3284
Size Price Stock Qty
5mg $229.00 In stock
10mg $295.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Cathepsin S inhibitor

Biological Activity

A slow, tight-binding reversible inhibitor of recombinant cathepsin S (Ki = 185 pM). Exhibits about 410-fold greater selectivity for cathepsin S compared to cathepsin B (Ki = 76 nM).
Targets cathepsin S          
Ki 185pM          

Cathepsin S inhibitor Dilution Calculator

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Chemical Properties

Cas No. 1373215-15-6 SDF Download SDF
Chemical Name [(3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl] N-methylcarbamate
Canonical SMILES CNC(=O)OC1COC2=C(C1NC(=O)C3=CC=C(C=C3)F)C=C(C=C2)N4CCN(CC4)C5COC5
Formula C25H29FN4O5 M.Wt 484.52
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

A novel Cathepsin S inhibitor. Cathepsin S is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases.