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Carprofen

Carprofen

Catalog No.

B1690

COX inhibitor

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Grouped product items
Size	Price	Stock	Qty
10mM (in 1mL DMSO)	$50.00	In stock
50mg	$42.00	In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background
Product Citation
Chemical Properties
Protocol
Quality Control

Background

Carprofen inhibits canine COX2 with IC50 of 0.03 mM.

Product Citation

1. KIMBERLY NELLENBACH, SEEMA NANDI, et al. "Neonatal Fibrin Scaffolds Promote Enhanced Cell Adhesion, Migration, and Wound Healing In Vivo Compared to Adult Fibrin Scaffolds." Cell Mol Bioeng. 2020 May 27;13(5):393-404. PMID:33184573

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	273.71
Cas No.	53716-49-7
Formula	C₁₅ H₁₂ClNO₂
Solubility	insoluble in H2O; ≥11.05 mg/mL in DMSO; ≥19.17 mg/mL in EtOH
Chemical Name	2-(6-chloro-9H-carbazol-2-yl)propanoic acid
SDF	Download SDF
Canonical SMILES	CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment [1]:
Cell lines	gastric mucosa
Preparation method	The solubility of this compound in DMSO is >11.1mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition	40 or 400 μg/mL
Applications	In the gastric mucosa of dogs, carprofen increased in vitro conductance and permeability to mannitol. Carprofen (400 μg/mL) caused sloughing of epithelial cells. Carprofen appeared to compromise gastric mucosal integrity and barrier function in dogs.
Animal experiment [2]:
Animal models	Dogs with chronic unilateral osteoarthritis of the stifle joint
Dosage form	10 days with a 30- to 60-day washout period
Application	Carprofen significantly suppressed PGE2 concentrations in blood at days 3 and 10. Carprofen significantly decreased gastric synthesis of PGE2 at day 3 but not day 10 of each treatment period. Carprofen decreased synovial fluid PGE2 concentrations in the affected and unaffected stifle joints at days 3 and 10.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1] Hicks M A, Hosgood G L, Morgan T W, et al. In vitro effect of carprofen and meloxicam on the conductance and permeability to mannitol and the histologic appearance of the gastric mucosa of dogs[J]. American journal of veterinary research, 2011, 72(4): 570-577. [2] Sessions J K, Reynolds L R, Budsberg S C. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis[J]. American journal of veterinary research, 2005, 66(5): 812-817.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 99.18%

Chemical structure

Carprofen