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Catalog No.
COX inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
In stock
In stock

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Carprofen inhibits canine COX2 with IC50 of 0.03 mM.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.53716-49-7
FormulaC15 H12ClNO2
Solubility≥11.05mg/mL in DMSO
Chemical Name2-(6-chloro-9H-carbazol-2-yl)propanoic acid
SDFDownload SDF
Canonical SMILESCC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.


Cell experiment [1]:

Cell lines

gastric mucosa

Preparation method

The solubility of this compound in DMSO is >11.1mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

40 or 400 μg/mL


In the gastric mucosa of dogs, carprofen increased in vitro conductance and permeability to mannitol. Carprofen (400 μg/mL) caused sloughing of epithelial cells. Carprofen appeared to compromise gastric mucosal integrity and barrier function in dogs.

Animal experiment [2]:

Animal models

Dogs with chronic unilateral osteoarthritis of the stifle joint

Dosage form

10 days with a 30- to 60-day washout period


Carprofen significantly suppressed PGE2 concentrations in blood at days 3 and 10. Carprofen significantly decreased gastric synthesis of PGE2 at day 3 but not day 10 of each treatment period. Carprofen decreased synovial fluid PGE2 concentrations in the affected and unaffected stifle joints at days 3 and 10.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.


[1] Hicks M A, Hosgood G L, Morgan T W, et al. In vitro effect of carprofen and meloxicam on the conductance and permeability to mannitol and the histologic appearance of the gastric mucosa of dogs[J]. American journal of veterinary research, 2011, 72(4): 570-577.

[2] Sessions J K, Reynolds L R, Budsberg S C. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis[J]. American journal of veterinary research, 2005, 66(5): 812-817.

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