BRD4770
Catalog No.
B4837
novel G9a(EHMT2) inhibitor
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BRD4770 is a histone methyltransferase G9a inhibitor with an IC50 of 6.3 μM and induces cell death[1].
In pancreatic cancer cell line PANC-1, BRD4770 reduces intracellular di- and trimethylated H3K9 levels through inhibition of G9a, induces senescence, and inhibits adherent-dependent and independent proliferation[1].
Reference:
[1]. Yuan Y, et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol, 2012, 7(7): 1152-7.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 413.47 |
| Cas No. | 1374601-40-7 |
| Formula | C25H23N3O3 |
| Solubility | insoluble in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | COC(c(cc1)cc2c1[n](CCCc1ccccc1)c(NC(c1ccccc1)=O)n2)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
