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BMS265246 |
potent and selective CDK1/2 inhibitor |
Sample solution is provided at 25 µL, 10mM.
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
| Description | BMS-265246 is a potent and selective inhibitor of CDK1 and CDK2 with IC50 values of 6 nM and 9 nM, respectively. | |||||
| Targets | CDK1/CyclinB | CDK2/CyclinE | CDK4/CyclinD | |||
| IC50 | 6 nM | 9 nM | 230 nM | |||
BMS265246 Dilution Calculator
BMS265246 Molarity Calculator
| Cas No. | 582315-72-8 | SDF | Download SDF |
| Chemical Name | (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2,6-difluoro-4-methylphenyl)methanone | ||
| Canonical SMILES | CCCCOC1=C2C=NNC2=NC=C1C(=O)C3=C(C=C(C=C3F)C)F | ||
| Formula | C18H17F2N3O2 | M.Wt | 345.34 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| Shipping Condition: | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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BMS265246 is a potent and selective Cdk1/Cdk2 inhibitor for Cdk1/cyclin-B (IC50 = 6 nM) and Cdk2/cyclin-E (IC50 = 9 nM). BMS265246 inhibits the activity of Cdk4/cycD (IC50 = 0.23 μM) and prevents A2780 Cytox with IC50 of 0.76 μM. BMS265246 when bound to Cdk2, shows the inhibitor resides within the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS265246 represents the most potent Cdk/Cdk2 selective analogue from this chemotype. A recent study shows that BMS-265246 inhibits cell proliferation with EC50 ranging from 0.293 μM-0.492 μM in HCT-116 cells. After treatment of BMS-265246, the dominant cell populations are G2-arrested cells having 4N DNA content, large round nuclei, and low DNA intensity.
