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β-Interleukin II (44-56)

Catalog No.
A1027
Cytokine,regulating WBC
Grouped product items
SizePriceStock Qty
5mg
$60.00
In stock
10mg
$100.00
In stock
25mg
$140.00
In stock

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Background

β-Interleukin II (44-56), (C68H113N19O19) is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH, MW= 1500.7. Interleukin 2 (IL-2) belongs to the interleukin family, a type of cytokine signaling molecule in the immune system, and it is a protein that regulates the activities of the white blood cells (leukocytes, often lymphocytes) responsible for immunity. IL-2, a soluble hormone-like mediator of the immune system, was the first interleukin molecule to be identified and characterized. It is necessary for the growth, proliferation, and differentiation of T cells to become 'effector' T cells. IL-2 is normally produced by T cells during an immune response and is necessary for the development of T cell immunologic memory, which depends upon the expansion of the number and function of antigen-selected T cell clones.IL-2 is also necessary for the maturation of a subset of T cells, termed regulatory T cells, during T cell development in the thymus.

 A1027_1

Figure1  Formula of b-Interleukin II (44-56)

A1027_2 

Figure2  Structure of Interleukin II 

Ref:

1. Cantrell DA, Smith KA (June 1984). "The interleukin-2 T-cell system: a new cell growth model". Science 224 (4655): 1312–6.

2. Smith KA (May 1988). "Interleukin-2: inception, impact, and implications". Science 240 (4856): 1169–76.

3. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (August 1995). "Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases". J. Immunol. 155 (3): 1151–64.

4. ThorntonAM, Shevach EM (July 1998). "CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production". J. Exp. Med. 188 (2): 287–96.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1500.74
FormulaC68H113N19O19
SynonymsH2N-Ile-Leu-Asn-Gly-Ile-Asn-Asn-Tyr-Lys-Asn-Pro-Lys-Leu-OH
Solubility≥150mg/mL in DMSO
SDFDownload SDF
Canonical SMILESC[[email protected]@H](CC)[[email protected]](N)C(N[[email protected]](CC(C)C)C(N[[email protected]](CC(N)=O)C(NCC(N[[email protected]]([[email protected]@H](CC)C)C(N[[email protected]](CC(N)=O)C(N[[email protected]](CC(N)=O)C(N[[email protected]](CC1=CC=C(O)C=C1)C(N[[email protected]](CCCCN)C(N[[email protected]](CC(N)=O)C(N2CCC[[email protected]]2C(N[[email protected]](CCCCN)C(N[[email protected]](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

β-Interleukin II (44-56)