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Atovaquone

Atovaquone

Catalog No.

B2078

unique naphthoquinone with broad-spectrum antiprotozoal activity

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Grouped product items
Size	Price	Stock	Qty
Evaluation Sample	$30.00	In stock
10mg	$40.00	In stock
50mg	$125.00	In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background
Chemical Properties
Protocol
Quality Control

Background

Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

Chemical Properties

Storage	Store at -20°C
M.Wt	366.84
Cas No.	95233-18-4
Formula	C₂₂H₁₉ClO₃
Solubility	insoluble in EtOH; insoluble in H2O; ≥17.03 mg/mL in DMSO
Chemical Name	3-(4-(4-chlorophenyl)cyclohexyl)-4-hydroxynaphthalene-1,2-dione
SDF	Download SDF
Canonical SMILES	ClC1=C([H])C([H])=C(C([H])=C1[H])C2([H])C([H])([H])C([H])([H])C(C(C3=O)=C(C4=C([H])C([H])=C([H])C([H])=C4C3=O)O[H])([H])C([H])([H])C2([H])[H]
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

In vitro experiment [1]:
Parasites	B. gibsoni
Preparation method	The solubility of this compound in DMSO is >17.03mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months.
Reacting condition	0 ~ 3.2 μM
Applications	The ΣFICs against WT B. gibsoni were 0.93, 0.82, 0.83 and 0.96 for Atovaquone and Proguanil at a ratio of 4:1, 3:2, 2:3 and 1:4, respectively. The ΣFICs against Atovaquone-resistant B. gibsoni were 0.88, 0.60, 0.77 and 0.88 at each ratio. The results implied that Atovaquone synergized the effects of Proguanil on WT and Atovaquone-resistant B. gibsoni.
Animal experiment [1]:
Animal models	Dogs infected with B. gibsoni
Dosage form	17 ~ 25 mg/kg; p.o.
Applications	In B. gibsoni-infected dogs, the combination of Atovaquone and Proguanil alleviated parasitemia. However, all dogs showed relapse of parasitic infection. In addition, some side effects were also observed. Self-limiting vomiting occurred in 2 dogs and hyperphosphatasia occurred in another dog. Mild increases in the alanine aminotransferase levels were confirmed in 2 dogs.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Iguchi A, Matsuu A, Fujii Y, Ikadai H, Hikasa Y. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197(3-4):527-33.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 99.14%

Chemical structure

Atovaquone