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weak antagonist of α1-adrenoceptors
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Anisodamine is a weak antagonist of α1-adrenergic receptors [1].

The adrenergic receptors play an important role in modulating sympathetic nervous system activity as well as a site of action for many therapeutic agents. The α1-adrenergic receptors contain three types, termed as α1A-, α1B-, and α1D. The α1-adrenergic receptor plays an essential role in smooth muscle, growth, neurological, and cardiovascular function [2]. With the binding of the endogenous ligands, epinephrine and norepinephrine, the adrenergic receptors are the prime mediators of smooth muscle contraction and hypertrophic growth [2].

Anisodamine was a natural tropane alkaloid predominantly found in the roots of A. tanguticus. Anisodamine weakly antagonized the activity of α1-adrenoceptors and blocked WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively [1]. Anisodamine showed antioxidant effects and protected against free radical-induced cellular damage [3].

[1] Varma D R, Yue T L.  Adrenoceptor blocking properties of atropine‐like agents anisodamine and anisodine on brain and cardiovascular tissues of rats[J]. British journal of pharmacology, 1986, 87(3): 587-594.
[2] Piascik M T, Perez D M.  α1-Adrenergic receptors: new insights and directions[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298(2): 403-410.
[3] Poupko J M, Baskin S I, Moore E.  The pharmacological properties of anisodamine[J]. Journal of Applied Toxicology, 2007, 27(2): 116-121.

Chemical Properties

StorageStore at -20°C
Cas No.55869-99-3
Synonyms6-hydroxy Hyoscyamine
Solubility≥13.32 mg/mL in EtOH; ≥13.65 mg/mL in H2O; ≥51.3 mg/mL in DMSO
Chemical Name6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
SDFDownload SDF
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure