In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Anisodamine is a weak antagonist of α1-adrenergic receptors .
The adrenergic receptors play an important role in modulating sympathetic nervous system activity as well as a site of action for many therapeutic agents. The α1-adrenergic receptors contain three types, termed as α1A-, α1B-, and α1D. The α1-adrenergic receptor plays an essential role in smooth muscle, growth, neurological, and cardiovascular function . With the binding of the endogenous ligands, epinephrine and norepinephrine, the adrenergic receptors are the prime mediators of smooth muscle contraction and hypertrophic growth .
Anisodamine was a natural tropane alkaloid predominantly found in the roots of A. tanguticus. Anisodamine weakly antagonized the activity of α1-adrenoceptors and blocked WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively . Anisodamine showed antioxidant effects and protected against free radical-induced cellular damage .
 Varma D R, Yue T L. Adrenoceptor blocking properties of atropine‐like agents anisodamine and anisodine on brain and cardiovascular tissues of rats[J]. British journal of pharmacology, 1986, 87(3): 587-594.
 Piascik M T, Perez D M. α1-Adrenergic receptors: new insights and directions[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298(2): 403-410.
 Poupko J M, Baskin S I, Moore E. The pharmacological properties of anisodamine[J]. Journal of Applied Toxicology, 2007, 27(2): 116-121.
|Storage||Store at -20°C|
|Solubility||≥13.32 mg/mL in EtOH; ≥13.65 mg/mL in H2O; ≥51.3 mg/mL in DMSO|
|Chemical Name||6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|