Toggle Nav
Close
  • Menu
  • Setting

Alisol B 23-acetate

Catalog No.
N1550
 
Grouped product items
SizePriceStock Qty
20mg
$192.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Alisol B 23-acetate is an agonist of farnesoid X receptor (FXR) [1]. 

FXR is a member of the nuclear receptor superfamily of ligand-activated transcription factors, playing a critical role in liver regeneration. Alisol B 23-acetate activates FXR-mediated regulation of genes involved in hepatocyte proliferation, potentially becoming a novel therapeutic option for facilitating efficient liver regeneration in patients subjected to liver resection [1]. 

In HepG2 cells transiently cotransfected with FXR expression plasmid, and FXR target gene,  bile salt export pump (BSEP) promoter reporter vector, Alisol B 23-acetate at doses of 0.1, 1 and 10 μM significantly increased luciferase activity. Additional increases were detected in cells treated with higher doses and reached a highest increase (4.3-fold) in cells treated with 10 μM of Alisol B 23-acetate [1]. 

In male C57BL6 mice received partial hepatectomy, Alisol B 23-acetate treatment (12.5, 25 or 50 mg/kg/d, p.o., for 7 days) significantly increased the ratio of liver regrowth, in a dose-dependent manner. In addition, significant increases in hepatocyte DNA synthesis and mitotic index could also be observed in Alisol B 23-acetate-treated mice, indicating that Alisol B 23-acetate promoted liver regeneration via enhancing hepatocyte proliferation [1]. 

Reference:

[1]. Meng Q, Chen X, Wang C, et al. Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor. Biochemical Pharmacology, 2014, 92(2): 289-298.

Chemical Properties

StorageStore at -20°C
M.Wt514.74
Cas No.26575-95-1
FormulaC32H50O5
SynonymsAlisol B 23-monoacetate; Alisol B monoacetate
Solubility≥51.5 mg/mL in DMSO; insoluble in H2O; ≥54.1 mg/mL in EtOH
Chemical Name[1-(3,3-dimethyloxiran-2-yl)-3-[(8S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3-oxo-1,2,5,6,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-17-yl]butyl] acetate
SDFDownload SDF
Canonical SMILESCC(CC(C1C(O1)(C)C)OC(=O)C)C2=C3CC(C4C5(CCC(=O)C(C5CCC4(C3(CC2)C)C)(C)C)C)O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control