|Actagardin tetracyclic antibiotic|
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||59165-34-3||SDF||Download SDF|
|Synonyms||Antibiotic A 3802-IV-3,Gardimycin|
|Canonical SMILES||O=C(CN1)N[[email protected]@H](CC2=CNC3=C2C=CC=C3)C(N[[email protected]@H](C(C)C)C(N[[email protected]](C(N[[email protected]]([[email protected]](C)SC[[email protected]](C(NCC(N[[email protected]@]([[email protected]@H]4C)([H])C(N[[email protected]@H](C(C)C)C(N[[email protected]@]5([H])[[email protected]@H](C)CC)=O)=O)=O)=O)([H])NC6=O)C(N[[email protected]@H](CC(C)C)C(N[[email protected]](C(N[[email protected]]([[email protected]@H](C)CC)([H])C(N[[email protected]]6CCC(O)=O)=O)=O)|
|Solubility||Soluble in DMSO||Storage||Store at -20°C|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
Actagardin is a tetracyclic antibiotic.
Actagardin is a tetracyclic antibiotic produced by several species of Actinoplanes.
In vitro: During the repeated fermentations of actagardin, two new compounds, named D and E, were isolated. Compound D was found to be twice as active as actagardin against Streptococcus pyogenes C 203 and four times more active than actagardin against Staphylococcus aureus ATCC 6538, S. pneumoniae UC 41, and S. aureus TOUR in the in-vitro tests .
In vivo: Animal study showed that compound D was also more effective than the parent compound actagardin against experimental infections in mice with either S. pyogenes C 203 or S. aureus TOUR, after sc administration. However, compound D was ineffective at doses up to 150 mg/kg when given orally to mice infected with S. pyogenes C 203. Moreover, compound D (LD50 1,250 mg/kg, mice, ip) was about 2.5 times more toxic than actagardine (3,310 mg/kg). In addition, compound E showed practically no in vitro activity up to 50 μg/ml against the tested organisms .
Clinical trial: So far, no clinical study has been conducted.
 Malabarba A, Landi M, Pallanza R, Cavalleri B. Physico-chemical and biological properties of actagardine and some acid hydrolysis products. J Antibiot (Tokyo). 1985 Nov;38(11):1506-11.