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4-ethylphenyl sulfate

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4-Ethylphenyl sulfate is a uremic toxin [1]. 

4-Ethylphenyl sulfate, derived from, or modulated by, the commensal microbiota, is a chemically related metabolite of p-cresol (4-methylphenol) which was reported to be a possible urinary biomarker for autism [1]. 4-Ethylphenyl sulfate was also known to be one of the small-molecular-weight organic compounds accumulated in patients with chronic renal failure (CRF), potentially used as an additional indicator for CRF [2]. 

In a mouse model of autism, 4-ethylphenyl sulfate displayed a striking 46-fold increase in serum levels of maternal immune activation (MIA) offspring, and Bacteroides fragilis completely restored this increase. In addition, daily treatment of 4-ethylphenyl sulfate (i.p., 30 mg/kg) from 3 weeks of age to 6 weeks of age, was sufficient to induce anxiety-like behavior similar to that observed in MIA offspring. Also, in the pre-pulse inhibition (PPI) test, 4-ethylphenyl sulfate-treated mice exhibited increased intensity of startle in response to the unconditioned primary stimulus, but no significant alterations in PPI [1]. 


[1]. Hsiao E Y, McBride S W, Hsien S, et al. The microbiota modulates gut physiology and behavioral abnormalities associated with autism. Cell, 2013, 155(7): 1451-1463.

[2]. Kikuchi K, Itoh Y, Tateoka R, et al. Metabolomic search for uremic toxins as indicators of the effect of an oral sorbent AST-120 by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2010, 878(29): 2997-3002.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.N/A
Solubilityinsoluble in EtOH; ≥20.2 mg/mL in DMSO; ≥28.25 mg/mL in H2O
Chemical Name4-ethylphenyl hydrogen sulfate
SDFDownload SDF
Canonical SMILESOS(OC1=CC=C(CC)C=C1)(=O)=O
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

4-ethylphenyl sulfate