In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
4-Ethylphenyl sulfate is a uremic toxin .
4-Ethylphenyl sulfate, derived from, or modulated by, the commensal microbiota, is a chemically related metabolite of p-cresol (4-methylphenol) which was reported to be a possible urinary biomarker for autism . 4-Ethylphenyl sulfate was also known to be one of the small-molecular-weight organic compounds accumulated in patients with chronic renal failure (CRF), potentially used as an additional indicator for CRF .
In a mouse model of autism, 4-ethylphenyl sulfate displayed a striking 46-fold increase in serum levels of maternal immune activation (MIA) offspring, and Bacteroides fragilis completely restored this increase. In addition, daily treatment of 4-ethylphenyl sulfate (i.p., 30 mg/kg) from 3 weeks of age to 6 weeks of age, was sufficient to induce anxiety-like behavior similar to that observed in MIA offspring. Also, in the pre-pulse inhibition (PPI) test, 4-ethylphenyl sulfate-treated mice exhibited increased intensity of startle in response to the unconditioned primary stimulus, but no significant alterations in PPI .
. Hsiao E Y, McBride S W, Hsien S, et al. The microbiota modulates gut physiology and behavioral abnormalities associated with autism. Cell, 2013, 155(7): 1451-1463.
. Kikuchi K, Itoh Y, Tateoka R, et al. Metabolomic search for uremic toxins as indicators of the effect of an oral sorbent AST-120 by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2010, 878(29): 2997-3002.
|Physical Appearance||A solid|
|Storage||Store at -20°C|
|Solubility||insoluble in EtOH; ≥20.2 mg/mL in DMSO; ≥28.25 mg/mL in H2O|
|Chemical Name||4-ethylphenyl hydrogen sulfate|
|Shipping Condition||Ship with blue ice, or upon other requests.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.|