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2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor

Catalog No.B5969
Size Price Stock Qty
10mM (in 1mL DMSO)
$50.00
In stock
250mg
$35.00
In stock
1g
$75.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

2-hexyl-4-Pentynoic Acid

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Chemical Properties

Cas No. 96017-59-3 SDF Download SDF
Chemical Name 2-(prop-2-yn-1-yl)octanoic acid
Canonical SMILES CCCCCCC(C(O)=O)CC#C
Formula C11H18O2 M.Wt 182.26
Solubility >15.45mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

2-hexyl-4-Pentynoic Acid is a potent and robust inhibitor of HDAC with IC50 value of 13 μM [1].

Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from ε-N-acetyl lysines on histones, allowing the histones to wrap the DNA more tightly. DNA expression is regulated by de-acetylation and acetylation.

2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor. In cerebellar granule cells, 2-hexyl-4-Pentynoic Acid (5 μM) significantly and dose-dependently increased acetylated histone H3 (Ac-H3) levels, and at 50-100 μM led to a maximal increase of 600-700%, compared with only a 200% increase by VPA at 100 μM. 2-hexyl-4-Pentynoic Acid also completely blocked glutamate-induced cell death at 50-100 μM. Also, 2-hexyl-4-Pentynoic Acid restored glutamate-induced neuronal loss. At 50 μM, 2-hexyl-4-Pentynoic Acid effectively increased HSP70-1a and HSP70-1b mRNA levels through HDAC inhibition [1].

Reference:
[1].  Leng Y, Marinova Z, Reis-Fernandes MA, et al. Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction. Neurosci Lett, 2010, 476(3): 127-132.