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15-acetoxy Scirpenol
mycotoxin that induce apoptotic cell death

Catalog No.C4698
Size Price Stock Qty
1mg
$219.00
In stock
5mg
$876.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

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Chemical structure

15-acetoxy Scirpenol

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Chemical Properties

Cas No. 2623-22-5 SDF Download SDF
Synonyms 4-Deacetylanguidin,NSC 267030
Chemical Name 12,13-epoxy-trichothec-9-ene-3α,4β,15-triol, 15-acetate
Canonical SMILES CC1=C[[email protected]]2([H])[[email protected]]([[email protected]]([[email protected]](O)[[email protected]]3O)(C)[[email protected]@]4(OC4)[[email protected]]3([H])O2)(COC(C)=O)CC1
Formula C17H24O6 M.Wt 324.4
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

15-acetoxy Scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the Fusarium genus [1]. 15-acetoxy Scirpenol could induce apoptotic cell death in human Jurkat T cells. Mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus Fusarium. Acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy Scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). The 50% inhibitory concentration (IC50) values of 15-acetoxy Scirpenol was 16.1 ng/ml [2]. In the Jurkat T cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-MAS), the populations of externalized PS-positive and PI-negative cells were 32.0% [2].

References:
[1] Peraica M, Radic B, Lucic A, et al.  Toxic effects of mycotoxins in humans[J]. Bulletin of the World Health Organization, 1999, 77(9): 754-766.
[2] Lee D H, Park T, Kim H W.  Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins[J]. Biological and Pharmaceutical Bulletin, 2006, 29(4): 648-654.