1-Oleoyl lysophosphatidic acid sodium salt
1-Oleoyl lysophosphatidic acid (LPA) is a naturally occurring phospholipid with various effects. LPA is widely distributed in many tissues. Similar to many other biomediators, LPA interacts with cells via specific cell surface receptors, such as G proteincoupled receptors, to induce biological effects.
In vitro: LPA could mediate signal transduction via Edg/LPA receptor, inducing the proliferation, migration, adhesion and antiapoptotic function of tumor cells. Additionally, LPA was found to elicit upregulation of VEGF, leading to an indirect influence on initiation and progression of malignancies. LPA could also stimulate matrix metalloproteinase secretion and tumor angiogenesis factor .
In vivo: LPA was tested for its vascular remodeling effect in a rat model of hypoxic pulmonary hypertension. Serum from animals in the hypoxic group showed higher chemoattractant properties toward rat primary lung fibroblasts, and such cell migration increase was prevented by the LPA receptor 1 and 3 antagonists. LPA also found to increase adhesive properties of human pulmonary artery endothelial cells, via the activation of LPA receptor 1 or 3 .
Clinical trial: Clinical retults showed that LPA concentration was significantly higher in pancreatic cancer patients. For diagnosis of pancreatic cancer, the sensitivity of LPA was 89.6% and the specificity 79. 4%. However, plasma LPA alteration had shown significant correlations with the tumor size, pathological stage, surrounding lymph nodes, as well as specific histopathological features .
 Yongling G, Shaokai W, Chenjie T, Jinfei C, Shukui W, Xiufeng C, Guangmei L, Pin L. Clinical evaluation on the determination of plasma lysophosphatidic acid concentration in Chinese human pancreatic cancer. International Journal of Hepatobiliary and Pancreatic Diseases 2011;1:6-12.
 Shlyonsky V,Naeije R,Mies F. Possible role of lysophosphatidic acid in rat model of hypoxic pulmonary vascular remodeling. Pulm Circ.2014 Sep;4(3):471-81.
|Physical Appearance||White solid|
|Storage||Store at -20°C|
|Solubility||<4.58mg/ml in PBS|
|Chemical Name||sodium (R,Z)-2-hydroxy-3-(oleoyloxy)propyl hydrogenphosphate|
|Canonical SMILES||CCCCCCCC/C([H])=C([H])\CCCCCCCC(OC[[email protected]](O)([H])COP([O-])(O)=O)=O.[Na+]|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|