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1-Deoxynojirimycin

In stock
Catalog No.
N1659
anti-cancer medicine
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
20mg
$200.00
In stock

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Imperatorin is reported as an anti-cancer medicine with many targets to induce cell apoptosis, such as enhancing p53 expression [1], inducing Mcl-1 degradation [2], activating activation of caspase-3, caspase-8, caspase-9 [3].
When tested with human cancer cell lines (SNU 449-liver cancer and HCT-15-colon cancer), imperatorin treatment promoted cell apoptosi in a dose-dependent manner via modulating expression of apotosis-related proteins [4]. In human embryonic kidney cells, imperatorin treatment significantly attenuated H2O2-induced ROS production [5]. When tested with human hepatoma HepG2 cells, administration of imperatorin inhibited cell proliferation in a time- and dose- dependent manner [3]. In human lung cancer H23 cells, imperatorin was shown to enhance the expression of p53 and induced cells apoptosis at sub-toxic concentrations [1].
In nude mouse model bearing HepG2 cells, treatment with imperatorin significantly suppressed tumor growth in a dose-dependent manner [3].
It is also reported that imperatorin inhibits voltage-gated K+ channels and ATP-sensitive K+ channels when tested with neuronal NG-108-15 cells [6].
References:
[1].    Choochuay, K., et al., Imperatorin sensitizes anoikis and inhibits anchorage-independent growth of lung cancer cells. J Nat Med, 2013. 67(3): p. 599-606.
[2].    Li, X., et al., Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma. Cancer Lett, 2014. 348(1-2): p. 146-55.
[3].    Luo, K.W., et al., Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways. Chemotherapy, 2011. 57(6): p. 449-59.
[4].    Rahman, A., et al., Growth inhibition of various human cancer cell lines by imperatorin and limonin from poncirus trifoliata rafin. Seeds. Anticancer Agents Med Chem, 2015. 15(2): p. 236-41.
[5].    Cao, Y., et al., Antioxidant effect of imperatorin from Angelica dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway. J Am Soc Hypertens, 2014. 8(8): p. 527-36.
[6].    Wang, Y.W., et al., Inhibitory effects of imperatorin on voltage-gated K(+) channels and ATP-sensitive K(+) channels. Pharmacol Rep, 2015. 67(1): p. 134-9.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt163.17
Cas No.19130-96-2
FormulaC6H13NO4
Solubility≥6mg/mL in DMSO
Chemical Name(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
SDFDownload SDF
Canonical SMILESC1C(C(C(C(N1)CO)O)O)O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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