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WZB117

Catalog No.
C4593
glucose transporter 1 (Glut1) inhibitor
Grouped product items
SizePriceStock Qty
5mg
$55.00
In stock
10mg
$88.00
In stock
25mg
$176.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

WZB117 (CAS 1223397-11-2) is a small-molecule inhibitor that targets glucose transporter 1 (GLUT1), a membrane protein responsible for basal glucose uptake essential to cellular bioenergetics. WZB117 selectively suppresses GLUT1-mediated glucose transport, exhibiting an IC50 of approximately 0.6 μM in various cancer cell lines. In vitro studies demonstrate that exposure to WZB117 reduces GLUT1 protein levels, intracellular ATP content, and expression of glycolytic enzymes, triggering activation of AMP-activated protein kinase (AMPK), downregulation of cyclin E2, reduced phosphorylated retinoblastoma, cell cycle arrest, senescence, and cell death by necrosis. In vivo, administration of WZB117 significantly decreases tumor growth in A549 lung cancer xenograft models, indicating its potential utility as a research tool in cancer metabolism studies.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt368.3
Cas No.1223397-11-2
FormulaC20H13FO6
SynonymsGlucose Transporter Inhibitor IV
Solubilityinsoluble in H2O; ≥18.4 mg/mL in DMSO; ≥42.6 mg/mL in EtOH
Chemical Name3-hydroxy-benzoic acid, (3-fluoro-1,2-phenylene)ester
SDFDownload SDF
Canonical SMILESOC1=CC=CC(C(OC2=CC=CC(F)=C2OC(C3=CC(O)=CC=C3)=O)=O)=C1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

WZB117

Related Biological Data

WZB117