Toggle Nav

Vialinin A

Catalog No.
USP/isopeptidase T (IsoT)/UCH-L1 DUB inhibitor
Grouped product items
SizePriceStock Qty
Ship with 5-10 days
Ship with 5-10 days
Ship with 5-10 days
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors


Vialinin A is a potent inhibitor of ubiquitin-specific peptidases with IC50 values of 1.5, 5.9 and 22.3 μM for ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB), respectively [1].

Ubiquitin-specific peptidases (USPs) are a series of proteases that deubiquitinate target proteins. The dynamic modification of a protein with ubiquitin can modify its function, localization and fate in the cell. Ubiquitin hydrolase plays an important role in immunology and infection [2].

In RBL-2H3 cells, vialinin A inhibited TNF-ɑ production and release and inhibited USP5 enzymatic activity. In USP5 siRNA-knockdown RBL-2H3 cells, vialinin A inhibited TNF-ɑ production and release in a dose dependent way. Also, the mRNA expression of TNF-ɑ was decreased significantly [2]. In RBL-2H3 cells, Vialinin A inhibited TNF-ɑ production with IC50 value of 0.09 nM. Also, it inhibited the release of interleukin 4, β-hexosaminidase and monocyte chemotactic protein 1, which suggested Vialinin A had anti-allergic activities [3].

[1].  Okada K, Ye YQ, Taniguchi K, et al. Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg Med Chem Lett, 2013, 23(15): 4328-4331.
[2].  Yoshioka Y, Ye YQ, Okada K, et al. Ubiquitin-specific peptidase 5, a target molecule of vialinin A, is a key molecule of TNF-α production in RBL-2H3 cells. PLoS One, 2013, 8(12): e80931.
[3].  Onose J, Xie C, Ye YQ, et al. Vialinin A, a novel potent inhibitor of TNF-alpha production from RBL-2H3 cells. Biol Pharm Bull, 2008, 31(5): 831-833.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
Cas No.858134-23-3
SolubilitySoluble in DMSO
Chemical Name[3,4-dihydroxy-2,5-bis(4-hydroxyphenyl)-6-(2-phenylacetyl)oxyphenyl] 2-phenylacetate
SDFDownload SDF
Canonical SMILESC1=CC=C(C=C1)CC(=O)OC2=C(C(=C(C(=C2C3=CC=C(C=C3)O)O)O)C4=CC=C(C=C4)O)OC(=O)CC5=CC=CC=C5
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Vialinin A