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Vandetanib hydrochloride

Catalog No.
A3906
VEGFR/EGFR inhibitor
Grouped product items
SizePriceStock Qty
25mg
$88.00
In stock
100mg
$225.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Vandetanib hydrochloride (CAS 524722-52-9) is a synthetic small-molecule kinase inhibitor targeting multiple receptor tyrosine kinases, including vascular endothelial growth factor receptor 2 (VEGFR2, IC50 = 40 nM), epidermal growth factor receptor (EGFR, IC50 = 500 nM), VEGFR3 (IC50 = 110 nM), and RET. Additionally, vandetanib selectively suppresses growth factor-induced proliferation of endothelial cells while sparing basal cell growth. Preclinical studies demonstrate inhibition of tumor angiogenesis, reduced tumor vascular density, enhanced apoptosis, and suppression of metastasis in tumor xenograft models. Vandetanib serves as a valuable research tool for oncology studies focusing on receptor tyrosine kinase signaling pathways.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt511.81
Cas No.524722-52-9
FormulaC22H25BrClFN4O2
SynonymsZactima hydrochloride; ZD6474 hydrochloride;ZD-6474 hydrochloride; ZD 6474 hydrochloride
Solubility≥51.2 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
Chemical NameN-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine hydrochloride
SDFDownload SDF
Canonical SMILESCN1CCC(COC2=C(OC)C=C(C(NC3=C(F)C=C(Br)C=C3)=NC=N4)C4=C2)CC1.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control