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Tin protoporphyrin IX dichloride

Catalog No.
B6432
heme oxygenase inhibitor
Grouped product items
SizePriceStock Qty
10mg
$137.00
In stock
25mg
$325.00
In stock
50mg
$575.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Tin protoporphyrin IX dichloride (CAS 14325-05-4) is a synthetic metalloporphyrin analog that selectively inhibits heme oxygenase-2 (HO-2), an enzyme abundant in neuronal and endothelial tissues responsible for catalyzing heme breakdown into biliverdin and carbon monoxide (CO). It shows selectivity for HO over endothelial nitric oxide synthase and soluble guanylyl cyclase, with IC50 values of 35 and 30 nM, respectively. In rat neonates, administration of this compound suppresses the physiological increase in HO activity post-birth and prevents neonatal hyperbilirubinemia, demonstrating utility in biomedical research on heme metabolism pathways.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt750.25
Cas No.14325-05-4
FormulaC34H32Cl2N4O4Sn
Solubilityinsoluble in EtOH; insoluble in H2O; ≥22.15 mg/mL in DMSO
SDFDownload SDF
Canonical SMILESC=CC1=C(/C2=C([H])/C(C(C)=C/3CCC([O-])=O)=NC3=C([H])/C4=N/C(C(C)=C4CCC([O-])=O)=C([H])\C5=C(C(C)=C([N-]5)/C([H])=C1\[N-]2)C=C)C.Cl.Cl.[Sn+4]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Tin protoporphyrin IX dichloride