Tin protoporphyrin IX dichloride
Catalog No.
B6432
heme oxygenase inhibitor
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Tin protoporphyrin IX dichloride (CAS 14325-05-4) is a synthetic metalloporphyrin analog that selectively inhibits heme oxygenase-2 (HO-2), an enzyme abundant in neuronal and endothelial tissues responsible for catalyzing heme breakdown into biliverdin and carbon monoxide (CO). It shows selectivity for HO over endothelial nitric oxide synthase and soluble guanylyl cyclase, with IC50 values of 35 and 30 nM, respectively. In rat neonates, administration of this compound suppresses the physiological increase in HO activity post-birth and prevents neonatal hyperbilirubinemia, demonstrating utility in biomedical research on heme metabolism pathways.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 750.25 |
| Cas No. | 14325-05-4 |
| Formula | C34H32Cl2N4O4Sn |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥22.15 mg/mL in DMSO |
| SDF | Download SDF |
| Canonical SMILES | C=CC1=C(/C2=C([H])/C(C(C)=C/3CCC([O-])=O)=NC3=C([H])/C4=N/C(C(C)=C4CCC([O-])=O)=C([H])\C5=C(C(C)=C([N-]5)/C([H])=C1\[N-]2)C=C)C.Cl.Cl.[Sn+4] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
