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TBCA

Catalog No.
C3957
CK2 inhibitor
Grouped product items
SizePriceStock Qty
5mg
$130.00
Ship with 5-10 days
10mg
$242.00
Ship with 5-10 days
25mg
$553.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Tetrabromocinnamic Acid (TBCA) is a new class of specific protein kinase CK2 inhibitors [1].

Protein kinases have been involved in catalyzing the phosphorylation of serine, threonine and tyrosine residues in protein substrates that play dominant roles in controlling nearly all cellular functions. The Ser/Thr-specific protein kinase CK2 has been implicated in signal transduction, gene expression, DNA repair, RNA and protein synthesis. CK2 is invariably elevated in a wide spectrum of tumours [1].

In vitro: TBCA was a selective, cell-permeable inhibitor of CK2 with an IC50 of 0.11 μM. The Ki value was 77 nM. TBCA showed minimal effect on a panel of 28 other kinases. TBCA induced cell death in Jurkat adult T cell leukemia cells with an DC50 of 7.7 μM [1]. TBCA dose-dependently inhibited platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP [2]. TBCA also significantly inhibited agonist-induced thromboxane A2 (TxA2) generation and ERK phosphorylation. TBCA significantly inhibited platelet spreading on immobilized fibrinogen surface and clot retraction mediated by integrin αIIbβ3 signaling [2].

References:
[1] Pagano M A, Poletto G, Di Maira G, et al.  Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors[J]. Chembiochem, 2007, 8(1): 129-139.
[2] Ryu S Y, Kim S.  Evaluation of CK2 inhibitor (E)-3-(2, 3, 4, 5-tetrabromophenyl) acrylic acid (TBCA) in regulation of platelet function[J]. European journal of pharmacology, 2013, 720(1): 391-400.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt463.7
Cas No.934358-00-6
FormulaC9H4Br4O2
SynonymsCasein Kinase II Inhibitor III,Tetrabromocinnamic Acid
Solubility≤1mg/ml in ethanol;2mg/ml in DMSO;5mg/ml in dimethyl formamide
Chemical Name(2E)-3-(2,3,4,5-tetrabromophenyl)-2-propenoic acid
SDFDownload SDF
Canonical SMILESBrC1=C(Br)C(Br)=C(Br)C=C1/C=C/C(O)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

TBCA