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surface antigen (208-215) [Hepatitis B Virus]

Catalog No.
Surface antigen used for signs of infection
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The nucleocapsid of hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated,  and they have been proposed to represent  the  phenotypic  expression  of the  four  major  genotypes  of HBV1. HBsAg subtypes show distinct geographical distributions2 and may provide historical information on the migration of ancestors carrying HBV of a particular subtype3.

The HBsAg, localized on the surface of the infectious Dane particle is considered to be the antigen responsible for conferring immunity to infection with hepatitis B4. A larger amount is found on filaments of 20-nm diameter and variable length. By far the most HBsAg is present on small, noninfectious, 20-nm particles5.


Figure1.  Surface antigen of the hepatitis B virus


1.Le Bouvier, G. L., Mccollum, R. W., Hierholzer, W. J., Irwin, G. R., Krugman, S. & Giles, J. P. (1972). Subtypes of Australia antigen and hepatitis-B virus.  Journal of the American Medical Association 222,  928-930

2.Courouce-Pauty, A. M., Plancon, A. & Soulier, J. P.  (1983). Distribution of HBsAg subtypes in the world.  Vox  sanguinis 44,  197-211.

3.Yamashita, Y., Kurashina, S., Miyakawa, Y. & Mayumi, M. (1975).  South-to-north gradient in distribution of the r determinant of hepatitis B surface antigen in Japan.  Journal of Infectious Diseases 131, 567-569.

4.A. M. Moriarty, B. H. Hoyer et al. Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector. Proc. Nati. Acad. Sci. 78:  2606-2610(1981).


Figure1.  Surface antigen of the hepatitis B virus

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Solubility≥89.9 mg/mL in DMSO; ≥25.05 mg/mL in H2O; ≥49.8 mg/mL in EtOH
SDFDownload SDF
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

surface antigen (208-215) [Hepatitis B Virus]