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Catalog No.
Amine-reactive biotinylation reagent, mid-length
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Sulfo-NHS-SS-11-biotin is a long-chain cleavable amine-reactive biotinylation reagent. The presence of the negatively charged sulfonate group in the chemical structure of sulfo-NHS-SS-11-biotin makes it a water-soluble biotinylation reagent that can be directly added to aqueous reactions without prior dissolution of organic solvents. Although no prior dissolution is required, an aqueous stock solution of sulfo-NHS-SS-11-biotin must be prepared rapidly and used immediately in case of the occurrence of hydrolysis of the active ester. Sulfo-NHS-SS-11-biotin has been used to react with amine-containing proteins and other molecules forming a complex which further interacts with avidin or streptavidin probes and to purify targeted molecules using affinity chromatography on a column of immobilized avidin or streptavidin.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Solubilityinsoluble in EtOH; ≥48.9 mg/mL in H2O; ≥49.2 mg/mL in DMSO
Chemical Namesodium 2,5-dioxo-1-((3-((3-oxo-3-((2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)amino)propyl)disulfanyl)propanoyl)oxy)pyrrolidine-3-sulfonate
SDFDownload SDF
Canonical SMILESO=C1N[[email protected]]2([H])[[email protected]]([[email protected]](CCCCC(NCCNC(CCSSCCC(ON3C(CC(S(=O)(O[Na])=O)C3=O)=O)=O)=O)=O)SC2)([H])N1
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

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