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Succinate Dehydrogenase Activity Colorimetric Assay Kit

Catalog No.
K2210
Detects succinate dehydrogenase activity, sensitive, high throughput screening (HTS).
Grouped product items
SizePriceStock Qty
100 assays
$1,588.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Succinate Dehydrogenase (SDH) or respiratory complex II or succinate-coenzyme Q reductase (SQR) is an enzyme complex that is present in the inner mitochondrial membrane. SDH is involved in both the electron transport chain and citric acid cycle. In mammals and many bacteria, SDH consists of 2 hydrophobic membrane anchor subunits (SDHC and SDHD) and 2 hydrophilic subunits, SDHA (flavoprotein) and SDHB (iron-sulfur protein). SDH oxidizes succinate to fumarate and transfers the electrons to ubiquinone. In humans, SDH deficiency can lead to a variety of phenotypes including myopathy, tumor formation and Leigh syndrome, a neurometabolic disorder. SDH can also prevent the generation of ROS (reactive oxygen species). Measurement of SDH activity has wide applications. The Succinate Dehydrogenase Activity Colorimetric Assay Kit provides a sensitive, fast and simple way for detection of SDH activity in various samples based on colorimetric method. In the assay, SDH converts succinate to fumarate and transfers the electron to an artificial electron acceptor (SDH Probe), which transforms the color from blue to a colorless product (depending upon the sample enzymatic activity). The assay is high-throughput adaptable. The kit can detect less than 0.1 mU SDH activity in a variety of samples.

Features & Properties

FeaturesSimple & rapid; High-throughput adaptable; This assay kit can detect less than 0.1 mU succinate dehydrogenase activity in a variety of samples.
ShippingBlue Ice
Storage ConditionsStore at -20°C.

Quality Control

Quality Control & DataSheet

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Product Citation

Storage

Store at -20°C.

Overview

Kit componentsSDH Assay Buffer, SDH Substrate Mix (Lyophilized), SDH Probe, DCIP Standard (2 mM), SDH Positive Control (Lyophilized)