In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ST638 is a tyrosine kinase inhibitor .
Tyrosine kinases are a family of protein kinases that phosphorylate the serine and threonine on other proteins. Phosphorylation of proteins by kinases has been involved in signal transduction and regulating cellular activity, such as cell division. Tyrosine kinases function in a variety of processes, such as mitogenesis, induction of mitosis, and transmembrane signaling .
In human platelets, preincubation with 50 μM of ST638 completely blocked the platelet aggregation induced with 0.05 unit/ml of thrombin. ST638 inhibited the increase of protein-tyrosine phosphorylation bands induced with thrombin in a dose-dependent manner. ST638 blocked the platelet aggregation and protein-tyrosine phosphorylation induced with thrombin in aspirin-treated platelets . In terminal erythroid differentiation of mouse erythroleukemia (MEL) cells, ST638 effectively induced differentiation in a synergistic manner . In rat and rabbit pulmonary artery cells, ST 638 (0.5 to 40 μmol/L) blocked IK in a dose-dependent manner .
 Asahi M, Yanagi S, Ohta S, et al. Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein[J]. FEBS letters, 1992, 309(1): 10-14.
 Levitzki A, Gazit A. Tyrosine kinase inhibition: an approach to drug development[J]. Science, 1995, 267(5205): 1782.
 Watanabe T, Shiraishi T, Sasaki H, et al. Inhibitors for protein-tyrosine kinases, ST638 and genistein, induce differentiation of mouse erythroleukemia cells in a synergistic manner[J]. Experimental cell research, 1989, 183(2): 335-342.
 Smirnov S V, Aaronson P I. Inhibition of vascular smooth muscle cell K+ currents by tyrosine kinase inhibitors genistein and ST 638[J]. Circulation Research, 1995, 76(2): 310-316.
|Physical Appearance||A crystalline solid|
|Storage||Store at -20°C|
|Solubility||≤30mg/ml in DMSO;50mg/ml in dimethyl formamide|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|